Ayten Amin directed her first short fiction Her Man in 2006. The film was screened at several international festivals including Clermont-Ferrand International Short Film Festival in France. It was also screened exclusively for a year on Canal Plus in France. In 2009, she directed another short fiction film titled Spring 89, produced by the Egyptian Film Center. Her film Tahrir 2011 (2011) was an official selection in the out of competition section at the 2011 Venice International Film Festival and won the CICT-IFTC award. It was an official selection at the TIFF Toronto International Film Festival 2011 and was nominated for a Cinema For Peace best documentary film award in 2012. In 2013, Ayten made her feature film debut with Villa69, which won the jury prize at the Abu Dhabi Film Festival. She directed the hit TV series Seventh Neighbor in 2017. Her second feature, Souad (2020), was a selection at the 2020 Cannes Film Festival.